Exploration of Ethnomedicinal Plants for Skin Diseases: A Network Pharmacology Approach to Revealing the Molecular Mechanisms of Traditional Herbs

R.F Yustisia; Risdayanti Risdayanti; R.A. Mauliantari

Authors

R.F Yustisia Universitas Muhammadiyah Mataram
Risdayanti Risdayanti Universitas Muhammadiyah Mataram
R.A. Mauliantari Universitas Muhammadiyah Mataram

Keywords:

ethnomedicin, plant drug, skin disease, network pharmacology, compound bioactive, mechanism molecular

Abstract

Improvement prevalence disease skin multifactorial and limitations therapy conventional push exploration Ethnomedicine uses a systems approach to discover more effective and safe drug candidates. This study aims to analyze and synthesize scientific evidence related to the use of ethnomedicinal plants in the treatment of skin diseases and identify the relationship between ethnomedicine and drug use. between bioactive compounds with target biological through a network pharmacology approach . The method used is qualitative research with an integrative review approach , using data sources from Google Scholar, Elicit, Scite.ai, Scispace, DOAJ, and Scopus, with the inclusion criteria of articles from 2016–2026, relevant, speaking English Indonesian, And available full-text . The results of the study indicate that plants with high ethnobotanical value contain secondary metabolites such as flavonoids, alkaloids, and terpenoids that contribute to antioxidant, antimicrobial, and anti-inflammatory activities. The network pharmacology approach reveals multi-target interactions through biological pathways such as inflammation, apoptosis, and metabolism, which are strengthened by bioinformatics and molecular docking analysis . The conclusion of this study confirms that the integration of ethnomedicine and network pharmacology is able to explain comprehensive molecular mechanisms of medicinal plants. The implementation has the potential support development drug evidence-based herbal scientific and become the basis for innovation in modern dermatological therapy.

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